• KEA2: Kinase Enrichment Analysis 2

  • Kinase Network by:
    • Kinase-Substrate Gene Set Library with Phosphosites
    • Kinase Domain Sequence Similarity
    • Kinase Substrate Similarity
    • Protein Binding Partners
    • Co-precipiatated Proteins (NURSA)
    • Differentially Expressed Genes Following Kinase Knockdown (L1000)
    • Regulatory Transcription Factors
    • Cell Line Fitness following Kinase Knockdown (Achilles)
    • Kinase Expression in Cancer Cell Lines (CCLE)
    • Kinase Copy Number Variation Across Cancer Cell Lines (COSMIC)
    • Kinase Mutation Across Cancer Cell Lines (COSMIC)
    • Kinase Abundance in Cell Lines/Tissues (ProteomicsDB)
    • Kinase Association with Disease (OMIM)
    • Associated phenotypes in Mice (MGIMPO)
    • Drugs Targeting Kinases (DrugBank)
    • Drugs that Inhibit Kinase by >90% (KinomeScan)
    • Membership in Biological Pathways
    • Gene Ontology Terms
    • GeneRIF Term Similarity
    • Similarity of Associated Terms from Text Mining

  • Protein Domains

Order Network:

  • Network Info
  • Cluster Info

We obtained protein domain data for all human kinases using the Universal Protein Resource (Uniprot) (The Uniprot Consortium, Nucleic Acids Research, 2014), which has domain annotations from Pfam (Punta, Nucleic Acids Research, 2014) and Simple Modular Architecture Tool (SMART) (Letunic, 2012, Nucleic Acids Research). We used the Jaccard index to generate a kinase similarity network based on shared protein domain.

For more information on these kinase networks visit:

KEA2 Kinome Resources
Click on a cluster or kinase label.