Kinase network based on similarity of substrates from the KEA gene-set library calculated using the Jaccard coefficient. Format: Excel,  TSV

Kinase network based on similarity of substrates at the phosphosite level from the KEA gene-set library calculated using the Jaccard coefficient. Format: Excel,  TSV

Kinase network based on similarity of interacting proteins calculated using the Jaccard coefficient. Format: Excel,  TSV

Kinase network based on similarity of similarity of amino acid sequence of the kinase domain calculated using ClustalW2 online sequence alignment tool. Format: Excel,  TSV

Kinase network based on similarity of putative regulatory transcription factors from the ChEA gene-set library calculated using the Jaccard coefficient. Format: Excel,  TSV

Kinase network based on similarity of kinase inhibitors from Kinomescan calculated using the weighted Jaccard coefficient. Format: Excel,  TSV

Kinase network based on similarity of drugs known to target kinases from DrugBank calculated using the Jaccard coefficient. Format: Excel,  TSV

Kinase network based on similarity of the pathways a kinase is a member of calculated using the Jaccard coefficient. Format: Excel,  TSV

Kinase network based on similarity of the signature of differentially expressed genes after kinase knowkdown from the LINCS L1000 experiments calculated using the cosine distance of the characteristic directions of gene expression. Format: Excel,  TSV

Kinase network based on similarity of kinase associations with phosphorylated genes from literature mining calculated using the Jaccard coefficient. Format: Excel,  TSV

Kinase network based on similarity of kinase associations with biological terms from literature mining calculated using the Jaccard coefficient. Format: Excel,  TSV

Download a Zip file with all Kinase networks. Zip

This library was made by manual curation of kinase-substrate interactions in the literature. The library terms are kinases and the elements are substrates with phosphosites. Format: Excel,  TSV

This is a database of kinase-substrate interactions at the phospho-site level with Pubmed IDs and resources. Format: Excel,  TSV

This is a database of kinase-substrate and kinase-binding interactions at the protein level with Pubmed IDs and resources. Format: Excel,  TSV

This library was made by manual curation of kinase-substrate interactions in the literature. The library terms are kinases and the elements are substrates without phosphosites. Format: Excel,  TSV

This library was made by text mining abstracts from papers that describe specific phosphosites on protein substrates. The terms are biological terms that are associated with specific protein substrates. Format: Excel,  TSV

This library was made by gathering phosphorylation substrates at the gene level from Stable Isotope Labeling by Amino acids in Cell culture (SILAC) phosphoproteomics experiments. The terms are SILAC experiments and the elements are protein substrates. Click on experiment terms to be redirected to the publication's pubmed page. Format: Excel,  TSV

This library was made by finding genes that were up-regulated after kinase perturbation from the Gene Expression Omnibus (GEO). The terms are kinase perturbation experiments and the elements are up-regulated genes. Format: Excel,  TSV

This library was made by finding genes that were down-regulated after kinase perturbation from the Gene Expression Omnibus (GEO). The terms are kinase perturbation experiments and the elements are down-regulated genes. Format: Excel,  TSV

This library was made by finding genes that were up-regulated after kinase perturbationfrom the Library of Integrated Network based Cellular Signatures (L1000) Connectivity Map. The terms are kinase perturbation experiments and the elements are up-regulated genes. Format: Excel,  TSV

This library was made by finding genes that were down-regulated after kinase perturbationfrom the Library of Integrated Network based Cellular Signatures (L1000) Connectivity Map. The terms are kinase perturbation experiments and the elements are down-regulated genes. Format: Excel,  TSV

Download a Zip file with all the gene set libraries. Zip

Biological Term Script

This python script was used for literature mining of abstracts. Format Script

Differentially Expressed Genes After Kinase Perturbation from GEO

This MatLab script was used to generate the gene set librarys from differentially expressed genes after kinase perturbation from the Gene Expression Omnibus. Script

Differentially Expressed Genes After Kinase Perturbation from the L1000 Connectivity Map

This MatLab script was used to generate the gene set library from differentially expressed genes afer kinase perturbation from the L1000 Connectivity Map. Script

Script Documentation

Documnentation for the above scripts. Script

Download a Zip file with all scripts. Zip